Potassium Hydroxide → 1-(3-Chlorophenyl)piperazine

HRID 237025

反応式

HRID 237025 の反応式
[N+](C1C=CC(S([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=3)[CH2:15][CH2:14]2)(=O)=O)=CC=1)([O-])=O.[OH-].[NH4+].[OH-].[K+]>CCOCC.[Cl-].[Cl-].[Cl-].[Ti+3]>[Cl:25][C:21]1[CH:20]=[C:19]([N:16]2[CH2:17][CH2:18][NH:13][CH2:14][CH2:15]2)[CH:24]=[CH:23][CH:22]=1

参加物

6

反応物 3

HCID 14797Potassium HydroxideHCID 14923Ammonium HydroxideHCID 10197251-(3-Chlorophenyl)-4-(4-nitrophenyl)sulfonylpiperazine

生成物 1

HCID 13551-(3-Chlorophenyl)piperazine

試薬・触媒・溶媒 2

HCID 10313229titanium(III) trichloride触媒HCID 3283Diethyl Ether溶媒

実験手順

1-[(p-Nitrophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine is reduced with aqueous titanium trichloride in ether solution by dropwise addition of aqueous TiCl3 until the purple color is no longer discharged. The reaction progress is followed by thin layer chromatography. Work-up with concentrated ammonium hydroxide and subsequently aqueous potassium hydroxide followed by isolation, drying, and concentration of the organic layer gives 1-[p-aminophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine.

後処理

  1. customdrying

出典と根拠

ORDレコード
ord-abb38bd69cbe41e4b74d1fd6d4d564b2
出典データセット
uspto-grants-1979_06
特許番号
US04159331

関連ノート

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