Hydrochloric Acid → HCID 68556345、化合物
反応式
C(OC(=O)[NH:7][C:8]1([CH2:22][CH2:23][CH2:24][O:25][CH3:26])[CH2:13][CH2:12][CH:11]([O:14][Si](C(C)(C)C)(C)C)[CH2:10][CH2:9]1)(C)(C)C.FC(F)(F)C(O)=O.Cl>ClCCl>[NH2:7][C:8]1([CH2:22][CH2:23][CH2:24][O:25][CH3:26])[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1参加物
5
実験手順
200 mg of the crude [4-(tert-butyl-dimethyl-silanyloxy)-1-(3-methoxy-propyl)-cyclohexyl]-carbamic acid tert-butyl ester (33, step a) were dissolved in 10 mL of dichloromethane and treated with 370 μL of trifluoroacetic acid. After stirring at room temperature until complete conversion was achieved, 2M aqueous hydrochloric acid was added, the mixture stirred for further 60 min and the aqueous phase evaporated. The crude aminoalcohol was lyophilized from water and used crude as hydrochloride in the next reaction. Rt=0.18 min, 0.37 min (Method C). Detected mass: 188.3 (M+H+).