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Ethyl 3-oxo-2-(2-phenylethyl)butanoate → 5-(2-Phenylethyl)-6-methyl-2-thiouracil
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 3-oxo-2-(2-phenylethyl)butanoate | HCID 219459 | — |
| 反応物 | Thiourea | HCID 2723790 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-(2-Phenylethyl)-6-methyl-2-thiouracil | HCID 12945970 | — |
反応手順
Ethyl α-(phenylethyl)acetoacetate (23.4 g) and thiourea (10.65 g) were added to a solution of sodium ethoxide in ethanol (100 ml) prepared from sodium (4.6 g). The mixture was refluxed for 51/2 hours and evaporated to dryness. The solid residue was dissolved in water and acetic acid was added to pH 4. The white precipitate was filtered off and recrystallised from ethanol to give 5-(2-phenylethyl)-6-methyl-2-thiouracil m.p. 210°-214°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04159329 |
| 出典データセット | uspto-grants-1979_06 |
| ORD ID | ord-4af3bbe7023a4bd1bc4c638c8bdf57ba |
| 出典メモ | uspto-grants-1979_06 |