反应详情

Ethyl α-(phenylethyl)acetoacetate (23.4 g) and thiourea (10.65 g) were added to a solution of sodium ethoxide in ethanol (100 ml) prepared from sodium (4.6 g). The mixture was refluxed for 51/2 hours and evaporated to dryness. The solid residue was dissolved in water and acetic acid was added to pH 4. The white precipitate was filtered off and recrystallised from ethanol to give 5-(2-phenylethyl)-6-methyl-2-thiouracil m.p. 210°-214°.

1. temperatureThe mixture was refluxed for 51/2 hours
2. customevaporated to dryness
3. dissolutionThe solid residue was dissolved in water
4. additionacetic acid was added to pH 4
5. filtrationThe white precipitate was filtered off
6. customrecrystallised from ethanol