Tetrahydrofuran → 2-Oxo-1,2,4a,8a-tetrahydroquinoline-6-carboxylic Acid
反応式
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]([O:14]C)=[O:13])[CH:8]=2)[N:3]=1.C1C[O:19]CC1>>[O:19]=[C:2]1[CH:11]=[CH:10][CH:9]2[CH:4]([CH:5]=[CH:6][C:7]([C:12]([OH:14])=[O:13])=[CH:8]2)[NH:3]1参加物
3
実験手順
A solution of methyl 2-chloroquinoline-6-carboxylate (60 mg, 0.271 mmol) in THF/5 N aqueous HCl (1:1, 2 mL) was heated to 60° C. in a heating block. LCMS shows major product 86% peak area corresponding to title compound with hydrolysis of methyl ester (m/z=189.9). The reaction was concentrated and used in the subsequent amide coupling steps without further purification.
出典と根拠
- ORDレコード
- ord-1358ff946528431bb7d34c1044ef0c2a
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08710043B2
反応ノート
読み込み中…