Ethylene Glycol → 2-Hydroxyethyl 3-(6-aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionate

HRID 2370915ノート

反応式

HRID 2370915 の反応式
Cl.Cl.[NH2:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][CH:11]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1.[CH2:26](O)[CH2:27][OH:28]>>[NH2:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][CH:11]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:12]([O:14][CH2:26][CH2:27][OH:28])=[O:13])=[CH:6][CH:5]=1

参加物

4

反応物 3

HCID 174Ethylene GlycolHCID 313Hydrochloric AcidHCID 694540453-(6-Aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionic acid hydrochloride

生成物 1

HCID 116533642-Hydroxyethyl 3-(6-aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionate

実験手順

0.4 ml of an HCl-saturated ether solution was added to a solution of 50.0 mg (0.16 mmol) of the compound from example 1i in 1 ml of ethylene glycol and stirred at RT for 1 h. The solution was then concentrated to dryness, and the residue was taken up in sat. NaHCO3 solution and extracted with EA several times. The combined EA extracts were dried, filtered and concentrated. The resulting residue was dried under high vacuum, resulting in 33 mg of the title compound in the form of a pale yellow oil.

後処理

  1. concentrationThe solution was then concentrated to dryness
  2. extractionextracted with EA several times
  3. dry with materialThe combined EA extracts were dried
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe resulting residue was dried under high vacuum

出典と根拠

ORDレコード
ord-e2bcf4895b3c47a09f26fe6c8a7e2c1d
出典データセット
uspto-grants-2014_04
特許番号
US08710232B2

反応ノート

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