N-bromobutanimide → HCID 67109249、化合物
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)=[CH:5][CH:4]=1.C1C(=O)N([Br:25])C(=O)C1>C(Cl)Cl>[Br:25][C:10]1[NH:11][C:12]2[C:17]([C:9]=1[C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2参加物
4
実験手順
3-(4-methoxyphenyl)-1H-indole was dissolved in 4 ml DCM. NBS (0.9 eq) was added in small portions over 2 min. The solvent was concentrated and the crude product was purified using HPLC (MeCN/H2O gradient). 103.3 mg 2-bromo-3-(4-methoxyphenyl)-1H-indole was obtained as a white solid.
後処理
- concentrationThe solvent was concentrated
- customthe crude product was purified
出典と根拠
- ORDレコード
- ord-4fdc1edd33784e7882437f88a9a4e4fd
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08710243B2
反応ノート
読み込み中…