Nitric Acid → 2-Hydroxy-5-nitrobenzene-1,3-dicarboxylic acid

HRID 237121ノート

反応式

HRID 237121 の反応式
S(=O)(=O)(O)O.[N+:6]([O-:9])(O)=[O:7].[OH:10][C:11]1[C:19]([C:20]([OH:22])=[O:21])=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]>C(O)(=O)C.O>[N+:6]([C:17]1[CH:16]=[C:12]([C:13]([OH:15])=[O:14])[C:11]([OH:10])=[C:19]([CH:18]=1)[C:20]([OH:22])=[O:21])([O-:9])=[O:7]

参加物

6

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 118121,3-Benzenedicarboxylic acid, 2-hydroxy- (9CI)

生成物 1

HCID 128964322-Hydroxy-5-nitrobenzene-1,3-dicarboxylic acid

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒3 回HCID 962Water溶媒

実験手順

A mixture of 40 ml of sulfuric acid and 33 ml of nitric acid is stirred for 10 minutes and then 10 ml of acetic acid is added. To this is added a suspension of 10 g of 2-hydroxyisophthalic acid (Org. Syn., Vol. 5, p. 617) in 20 ml of acetic acid slowly with cooling in a water bath. A 10 ml portion of acetic acid is added. The reaction mixture is dissolved in water and extracted with ether. The ether is washed with saturated saline, dried over sodium sulfate and evaporated giving 5-nitro-2-hydroxyisophthalic acid as an orange oil.

後処理

  1. additionTo this is added
  2. temperaturewith cooling in a water bath
  3. extractionextracted with ether
  4. washThe ether is washed with saturated saline
  5. dry with materialdried over sodium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-337a81ecb4784376bac0753f75d8210c
出典データセット
uspto-grants-1979_06
特許番号
US04159384

反応ノート

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