Ammonium Hydroxide → HCID 15042212、化合物

HRID 2371741ノート

反応式

HRID 2371741 の反応式
[Cl:1][C:2]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9](Cl)=[O:10])[CH2:6]1.[OH-].[NH4+:18]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]([NH2:18])=[O:10])[CH2:6]1

参加物

5

反応物 2

HCID 14923Ammonium HydroxideHCID 199062193-(2,4-Dichlorophenoxy)-1-azetidinecarbonyl chloride

生成物 1

HCID 15042212HCID 15042212、化合物収率 87.9%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A stirred solution of 4.8 g (0.017 mole) of 3-(2,4-dichlorophenoxy)-1-azetidinecarbonyl chloride in 20 mL of tetrahydrofuran was treated with 3.0 mL (0.05 mole) of 57% ammonium hydroxide. After stirring for 5 h, the reaction mixture was diluted with 200 mL of water and the precipitated solid collected by filtration (4.1 g). The crude product was recrystallized from acetonitrile/water to yield 3.9 g (87.9%) of white crystals, mp 169°-170° C.

後処理

  1. filtrationthe precipitated solid collected by filtration (4.1 g)
  2. customThe crude product was recrystallized from acetonitrile/water

出典と根拠

ORDレコード
ord-8a451f886de543d88136bbef2c1cdb22
出典データセット
uspto-grants-1992_03
特許番号
US05095014

反応ノート

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