Methylamine → HCID 15042214、化合物

HRID 2371743ノート

反応式

HRID 2371743 の反応式
[Cl:1][C:2]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9](Cl)=[O:10])[CH2:6]1.[CH3:17][NH2:18]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]([NH:18][CH3:17])=[O:10])[CH2:6]1

参加物

5

反応物 2

HCID 6329MethylamineHCID 199062193-(2,4-Dichlorophenoxy)-1-azetidinecarbonyl chloride

生成物 1

HCID 15042214HCID 15042214、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A stirred solution of 4.8 g (0.017 mole) of 3-(2,4-dichlorophenoxy)-1-azetidinecarbonyl chloride in 20 mL of tetrahydrofuran was treated with 4 mL (0.05 mole) of 40% aqueous monomethylamine. After stirring for 5 h, the reaction mixture was diluted with 200 mL of water and the precipitated solid collected by filtration (4.6 g). The crude product was recrystallized from acetonitrile yielding 3.4 g (72.7%) of coarse white powder, mp 140°-141° C.

後処理

  1. filtrationthe precipitated solid collected by filtration (4.6 g)
  2. customThe crude product was recrystallized from acetonitrile yielding 3.4 g (72.7%) of coarse white powder, mp 140°-141° C.

出典と根拠

ORDレコード
ord-4f829976f4234cbe95b96e195e4f29a2
出典データセット
uspto-grants-1992_03
特許番号
US05095014

反応ノート

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