BW284C51 → Acrylodan

HRID 237192

反応式

HRID 237192 の反応式
[I-].C(S[CH2:6][CH2:7][N+:8]([CH3:11])([CH3:10])C)(=O)C.[N+](C1C=CC(SS[C:26]2[CH:27]=[CH:28][C:29]([N+]([O-])=O)=[C:30]([CH:34]=2)[C:31](O)=O)=CC=1C(O)=O)([O-])=O.SC[C@H]([C@@H](CS)O)O.[OH2:46].Cl.NC1C2C(N=C3C=1CCCC3)=CC=CC=2.[CH3:63][N+](C1C=CC(CCC(CCC2C=CC([N+](CC=C)(C)C)=CC=2)=O)=CC=1)(CC=C)C.C[N+]([CH2:97][CH2:98][CH2:99]CCCCCCC[N+](C)(C)C)(C)C.CC[N+](C1C=CC=C(O)C=1)(C)C.C[N+](C1C=C(C(=O)CC(F)(F)F)C=CC=1)(C)C.C/C=C1/[C@H]2C=C(C)C[C@]/1(N)C1C=CC(NC=1C2)=O>>[CH3:11][N:8]([C:7]1[CH:6]=[CH:31][C:30]2[CH:34]=[C:26]([C:99]([CH:98]=[CH2:97])=[O:46])[CH:27]=[CH:28][C:29]=2[CH:63]=1)[CH3:10]

参加物

10

反応物 9

HCID 1338BW284C51HCID 2968DecamethoniumHCID 3202EdrophoniumHCID 62545,5'-Dithiobis(2-nitrobenzoic Acid)HCID 74629Acetylthiocholine iodideHCID 446094D-1,4-DithiothreitolHCID 907504(-)-IsoselagineHCID 64200021,2,3,4-Tetrahydro-9-acridinamine hydrochloride hydrate (1:?:?)HCID 69751146m-(N,N,N-trimethylammonio)trifluoromethylacetophenone

生成物 1

HCID 104901Acrylodan

実験手順

Inhibitors and Substrates-Acetylthiocholine iodide, 5,5′-dithiobis(2-nitrobenzoic acid) (Ellman's reagent), dithiothreitol, tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate), BW284c51, decamethonium, and edrophonium were purchased from Sigma. m-(N,N,N-trimethylammonio)trifluoromethylacetophenone (TFK+) and (−)huperzine A were purchased from Calbiochem. Acrylodan was obtained from Molecular Probes (Eugene, Oreg.). Fasciculin 2 (purified from the venom of Dendroaspis angusticeps) was a gift of Dr. Pascale Marchot (University of Marseille, France). Drs. Yacov Ashani and Bhupendra P. Doctor (Walter Reed Army Research Center, Washington, D.C.) kindly provided 7-((methylethoxy) phosphinyl)-oxyl)-1-methylquinolinium iodide (MEPQ) and procainamide-linked Sepharose CL-4B resin. m-tert-Butyl trifluoromethylacetophenone (TFK+) was synthesized as described (21) and kindly provided by Dr. Daniel Quinn, University of Iowa, Iowa City, Iowa. All other chemicals were of the highest grade commercially available.

出典と根拠

ORDレコード
ord-85a0f7713e78471f8f2b54ff219b3f42
出典データセット
uspto-grants-2014_02
特許番号
US08642273B2

関連ノート

読み込み中…