Thionyl Chloride → 2-(4-Methoxyphenyl)propanoyl chloride
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:5][CH:4]=1.S(Cl)([Cl:16])=O>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:13])[C:10]([Cl:16])=[O:11])=[CH:5][CH:4]=1参加物
3
実験手順
Under an argon atmosphere, 2-(4-methoxyphenyl)propanoic acid (synthesized by the process of I. Shiina, et al., Eur. J. Org. Chem., 5887-5890 (2008)) (1.20 g, 6.66 mmol) was dissolved in thionyl chloride (6.00 mL, 82.6 mmol) and the solution was heated to reflux for 27 hours. After cooling to room temperature, the mixture was concentrated under reduced pressure to give the crude product of 2-(4-methoxyphenyl)propanoyl chloride (16) as a colorless oil. The product was used in the following reaction without further purification.
後処理
- temperaturethe solution was heated
- temperatureto reflux for 27 hours
- concentrationthe mixture was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-aaa3d34f55d8495691df1b37dd6c408c
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642281B2
反応ノート
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