Thionyl Chloride → HCID 14946077、化合物

HRID 237235

反応式

HRID 237235 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:5][CH:4]=1.S(Cl)([Cl:16])=O>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:13])[C:10]([Cl:16])=[O:11])=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 257576p-Methoxyphenylpropionic acid

生成物 1

HCID 14946077HCID 14946077、化合物

実験手順

Under an argon atmosphere, 2-(4-methoxyphenyl)propanoic acid (synthesized by the process of I. Shiina, et al., Eur. J. Org. Chem., 5887-5890 (2008)) (1.20 g, 6.66 mmol) was dissolved in thionyl chloride (6.00 mL, 82.6 mmol) and the solution was heated to reflux for 27 hours. After cooling to room temperature, the mixture was concentrated under reduced pressure to give the crude product of 2-(4-methoxyphenyl)propanoyl chloride (16) as a colorless oil. The product was used in the following reaction without further purification.

後処理

  1. temperaturethe solution was heated
  2. temperatureto reflux for 27 hours
  3. concentrationthe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-aaa3d34f55d8495691df1b37dd6c408c
出典データセット
uspto-grants-2014_02
特許番号
US08642281B2

関連ノート

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