Aluminium lithium hydride → 1-(1-Benzylpyrrolidin-3-yl)ethan-1-amine

HRID 2372355ノート

反応式

HRID 2372355 の反応式
[CH2:1]([N:8]1[CH2:12][CH:11]([C:13](=[N:15]O)[CH3:14])[CH2:10][C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:15][CH:13]([CH:11]1[CH2:10][CH2:9][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:12]1)[CH3:14]

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 85126173HCID 85126173、化合物

生成物 1

HCID 190005451-(1-Benzylpyrrolidin-3-yl)ethan-1-amine収率 102.7%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

30 ml of anhydrous tetrahydrofuran (THF) was added to 650 mg of 1-benzyl-4-(1-hydroxyiminoethyl)-2-pyrrolidone and 500 mg of lithium aluminum hydride and the obtained mixture was refluxed for 20 h. After the decomposition of lithium aluminum hydride, the precipitate was filtered and washed thoroughly with THF. The wash solution was added to the filtrate. The solvent was distilled off under reduced pressure to obtain 587 mg of the desired compound in the form of a light yellow oil.

後処理

  1. temperaturethe obtained mixture was refluxed for 20 h
  2. filtrationAfter the decomposition of lithium aluminum hydride, the precipitate was filtered
  3. washwashed thoroughly with THF
  4. additionThe wash solution was added to the filtrate
  5. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-f3c0550f610847ffaa4b4803b3204c42
出典データセット
uspto-grants-1992_03
特許番号
US05098912

反応ノート

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