HCID 67798252、化合物 → HCID 67798074、化合物

HRID 2372480ノート

反応式

HRID 2372480 の反応式
[CH2:1]([O:3][C:4]1([C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([OH:18])[CH:12]=2)[CH2:9][CH2:8][O:7][CH:6]([CH3:10])[CH2:5]1)[CH3:2]>C(O)C.[Pd]>[CH2:4]([O:18][C:13]1[CH:12]=[C:11]([C:4]2([O:3][CH2:1][CH3:2])[CH2:9][CH2:8][O:7][CH:6]([CH3:10])[CH2:5]2)[CH:16]=[C:15]([F:17])[CH:14]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 1

HCID 67798252HCID 67798252、化合物

生成物 1

HCID 67798074HCID 67798074、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The (2SR,4SR)-4-ethoxy-4-(5-fluoro-3-hydroxyphenyl)-2-methyltetrahydropyran, used as a starting material, was obtained by hydrogenolysis of a solution of (2SR,4SR)-4-(3-benzyloxy-5-fluorophenyl)-4-ethoxy-2-methyltetrahydropyran (2.6 g, described in Note i. below Table X in Example 45) in ethanol (25 ml) in the presence of 10% palladium-on-charcoal catalyst (0.26 g). The mixture was filtered and the filtrate was evaporated. There was thus obtained the required starting material (1.69 g, 89%), as an oil.

出典と根拠

ORDレコード
ord-d0c564b0698b4766b55c5cdf33f614aa
出典データセット
uspto-grants-1992_03
特許番号
US05098930

反応ノート

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