U 84935 → HCID 70059045、化合物

HRID 2372716ノート

反応式

HRID 2372716 の反応式
[CH:1]1([C:4]2[O:8][N:7]=[C:6]([C:9]3[N:10]=[CH:11][N:12]4[C:21]5[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=5[C:15]5=[N:22][CH2:23][CH2:24][N:14]5[C:13]=34)[N:5]=2)[CH2:3][CH2:2]1.[C:25]([OH:34])(=[O:33])[C@@H:26]([C@H:28]([C:30]([OH:32])=[O:31])[OH:29])[OH:27]>ClCCl>[C:30]([C@@H:28]([C@H:26]([C:25]([OH:34])=[O:33])[OH:27])[OH:29])([OH:32])=[O:31].[CH:1]1([C:4]2[O:8][N:7]=[C:6]([C:9]3[N:10]=[CH:11][N:12]4[C:21]5[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=5[C:15]5=[N:22][CH2:23][CH2:24][N:14]5[C:13]=34)[N:5]=2)[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 131796U 84935HCID 444305L-Tartaric acid

生成物 1

HCID 70059045HCID 70059045、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Equimolar amounts of 5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydrodiimidazo[1,5-a:1',2'-c]quinazoline (0.64 g) and L-tartaric acid (0.30 g) was stirred in dichloromethane (25 ml) until a clear solution was obtained. The solvent was removed by evaporation in vacuo and the residue was triturated with isopropyl alcohol. The crystalline precipitate was filtered off and recrystallized from ethanol yielding the title compound as pale crystals, m.p. 160°-163° C. (Compound 41).

後処理

  1. customwas obtained
  2. customThe solvent was removed by evaporation in vacuo
  3. customthe residue was triturated with isopropyl alcohol
  4. filtrationThe crystalline precipitate was filtered off
  5. customrecrystallized from ethanol yielding the title compound as pale crystals, m.p. 160°-163° C. (Compound 41)

出典と根拠

ORDレコード
ord-3ff57096c9694f3d9418f2558d2626f8
出典データセット
uspto-grants-1992_03
特許番号
US05100895

反応ノート

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