1,1'-Carbonyldiimidazole → HCID 19902259、化合物

反応式

C(N1C=CN=C1)(N1C=CN=C1)=O.[CH:13]1([C:22]([OH:24])=O)[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14]1.[F:25][C:26]1[CH:40]=[CH:39][C:29]2[C:30]([CH:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)=[N:31][O:32][C:28]=2[CH:27]=1>ClCCl>[F:25][C:26]1[CH:40]=[CH:39][C:29]2[C:30]([CH:33]3[CH2:34][CH2:35][N:36]([C:22]([CH:13]4[C:21]5[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=5)[CH2:15][CH2:14]4)=[O:24])[CH2:37][CH2:38]3)=[N:31][O:32][C:28]=2[CH:27]=1

参加物

実験手順

4.2 g of carbonyldiimidazole are added to 3.7 g of 1-indanecarboxylic acid (Synthesis (1987) 845) dissolved in 15 ml of dichloromethane. After stirring for 1 hour 30 minutes at room temperature, 5 g of 6-fluoro-3-piperid-4-yl-1,2-benzisoxazole, dissolved in 10 ml of dichloromethane, are added. The mixture is stirred for 48 hours at room temperature and then concentrated to dryness and the residue is extracted with ethyl acetate. The organic phase is washed with hydrochloric acid, then with sodium bicarbonate solution and finally with water. It is dried over magnesium sulfate and concentrated. The oil obtained is used without further treatment.