(4-{[Benzyl({[3,5-bis(trifluoromethyl)benzoyl]amino}sulfonyl)amino]methyl}cyclohexyl)methyl phenylcarbamate → (4-{[({[3,5-Bis(trifluoromethyl)benzoyl]amino}sulfonyl)amino]methyl}cyclohexyl)methyl phenylcarbamate

HRID 23731ノート

反応式

HRID 23731 の反応式
[C:1]1([NH:7][C:8](=[O:46])[O:9][CH2:10][CH:11]2[CH2:16][CH2:15][CH:14]([CH2:17][N:18](CC3C=CC=CC=3)[S:19]([NH:22][C:23](=[O:38])[C:24]3[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[C:26]([C:34]([F:37])([F:36])[F:35])[CH:25]=3)(=[O:21])=[O:20])[CH2:13][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.C(OCC)(=O)C.[OH-].[OH-].[Pd+2]>[C:1]1([NH:7][C:8](=[O:46])[O:9][CH2:10][CH:11]2[CH2:12][CH2:13][CH:14]([CH2:17][NH:18][S:19]([NH:22][C:23](=[O:38])[C:24]3[CH:29]=[C:28]([C:30]([F:32])([F:31])[F:33])[CH:27]=[C:26]([C:34]([F:35])([F:36])[F:37])[CH:25]=3)(=[O:20])=[O:21])[CH2:15][CH2:16]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 1

HCID 22574466(4-{[Benzyl({[3,5-bis(trifluoromethyl)benzoyl]amino}sulfonyl)amino]methyl}cyclohexyl)methyl phenylcarbamate

生成物 1

HCID 22574490(4-{[({[3,5-Bis(trifluoromethyl)benzoyl]amino}sulfonyl)amino]methyl}cyclohexyl)methyl phenylcarbamate

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 21584119Ethylacetate methanol溶媒

実験手順

7 (31.5 mg, 47 mmole, 1.0 eq) was dissolved in 4/1 methanol/ethyl acetate (1.25 mL) and 15 mg of 20% palladium hydroxide on carbon (wet) was added. The vessel was evacuated and charged with hydrogen and stirred overnight. The catalyst was fitered over celite and the filtrate evaporated to give the title compound in nearly quantitative yield. 1H NMR (500 MHz, DMSO-d6): δ 12.23 (br s, 1H), 9.54 (s, 1H), 8.50 (s, 2H), 8.28 (s, 1H), 7.42 (d, 2H), 7.24 (t, 2H), 6.95 (t, 1H), 3.84 (d, 2H), 2.70 (br s, 2H), 1.54-1.38 (m, 2H), 0.88 (m, 4H).

後処理

  1. additionwas added
  2. customThe vessel was evacuated
  3. additioncharged with hydrogen
  4. customthe filtrate evaporated

出典と根拠

ORDレコード
ord-ccb3f757053e4e919cb68765113bad58
出典データセット
uspto-grants-2005_02
特許番号
US06852738B2

反応ノート

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