Ammonia → 7-Nitroquinazolin-4-amine

HRID 237317

反応式

HRID 237317 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH3:15]>CO>[N+:12]([C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH2:15])=[N:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1)([O-:14])=[O:13]

参加物

4

反応物 2

HCID 222AmmoniaHCID 8306804-Chloro-7-nitroquinazoline

生成物 1

HCID 136977987-Nitroquinazolin-4-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 1.6 g of 4-chloro-7-nitroquinazoline in 50 ml 7N ammonia in methanol was stirred overnight at rt and concentrated to dryness. The solid was suspended in water, filtered, rinsed with water followed by ether and dried overnight in vacuum oven to provide 0.98 g of 7-nitroquinazolin-4-amine (Compound 98-2).

後処理

  1. concentrationconcentrated to dryness
  2. filtrationfiltered
  3. washrinsed with water
  4. customdried overnight in vacuum oven

出典と根拠

ORDレコード
ord-9c94a77e0d38476da509652811c7b21c
出典データセット
uspto-grants-2014_02
特許番号
US08642582B2

関連ノート

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