Methanol → HCID 12115479、化合物
反応式
[Na].[CH3:2][CH:3]([C:8]1[CH:14]=[C:13]([C:15](F)([C:20]([F:23])([F:22])[F:21])[C:16]([F:19])([F:18])[F:17])[CH:12]=[CH:11][C:9]=1[NH2:10])[CH2:4][CH:5]([CH3:7])[CH3:6].[CH3:25][OH:26]>>[CH3:2][CH:3]([C:8]1[CH:14]=[C:13]([C:15]([O:26][CH3:25])([C:20]([F:23])([F:22])[F:21])[C:16]([F:19])([F:18])[F:17])[CH:12]=[CH:11][C:9]=1[NH2:10])[CH2:4][CH:5]([CH3:7])[CH3:6]参加物
4
実験手順
Sodium (533 mg, 23 mmol) was dissolved in methanol (40 ml), followed by adding thereto 2-(1,3-dimethylbutyl)-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]aniline (2 g, 5.8 mmol), and the resulting mixture was stirred at reflux temperature for 3 hours. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate and then concentrated under reduced pressure, and the resulting residue was separated and purified by silica gel column chromatography (hexane:ethyl acetate=6:1) to obtain 1.8 g of the desired compound.