1,1'-Carbonyldiimidazole → (S)-hexahydro-3H-pyrrolo[1,2-c]imidazol-3-one
反応式
[NH2:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][NH:4]1.[C:8](N1C=CN=C1)(N1C=CN=C1)=[O:9]>C(Cl)Cl>[CH2:2]1[NH:1][C:8](=[O:9])[N:4]2[CH2:5][CH2:6][CH2:7][C@@H:3]12参加物
4
実験手順
(S)-2-(Aminomethyl)pyrrolidine (250 mg) and carbonyldiimidazole (400 mg, 1.0 equiv.) were dissolved in DCM (50 mL). The resulting mixture was stirred at room temperature for 18 hours, then concentrated under vacuum. The residue was purified by flash column chromatography (SPE cartridge, SiO2), using DCM-methanol (95:5) as eluent to afford the title compound as colourless solid (150 mg, 50% yield).
後処理
- concentrationconcentrated under vacuum
- customThe residue was purified by flash column chromatography (SPE cartridge, SiO2)
出典と根拠
- ORDレコード
- ord-dffd5b37ef134704983f72fd548a7e20
- 出典データセット
- uspto-grants-2008_12
- 特許番号
- US07459456B2
反応ノート
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