Methylamine → 3'-Chloro-4'-fluoro-4-hydroxy-biphenyl-3-carboxylic acid (2-biphenyl-4-yl-1(S)-methylcarbamoyl-ethyl)-amide

反応式

[C:1]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:6]=[CH:5][C:4]([CH2:7][C@H:8]([NH:12][C:13]([C:15]2[CH:16]=[C:17]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[C:24]([Cl:29])[CH:23]=3)[CH:18]=[CH:19][C:20]=2[OH:21])=[O:14])[C:9]([OH:11])=O)=[CH:3][CH:2]=1.COC(=O)[C@@H:39]([NH:53]C(C1C=C(C2C=CC(F)=C(Cl)C=2)C=CC=1O)=O)CC1C=CC(C2C=CC=CC=2)=CC=1.CN.C1COCC1.C[Si](Br)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[C:1]1([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:2]=[CH:3][C:4]([CH2:7][C@H:8]([NH:12][C:13]([C:15]2[CH:16]=[C:17]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[C:24]([Cl:29])[CH:23]=3)[CH:18]=[CH:19][C:20]=2[OH:21])=[O:14])[C:9](=[O:11])[NH:53][CH3:39])=[CH:5][CH:6]=1