5-Chloro-4-methyl-3-nitropyridin-2-amine → HCID 68532432、化合物
反応式
[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([N+:9]([O-])=O)[C:5]([NH2:8])=[N:6][CH:7]=1.[H][H]>CO.O=[Pt]=O>[ClH:1].[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1参加物
5
実験手順
The material from Step 1 (1.0 g) was dissolved in MeOH (300 ml) and PtO2 (40 mg) was added. The mixture was subjected to hydrogen (50 psi) in a Parr shaker for 3.5 h, then filtered through Celite and to the filtrate was added conc. HCl (1 ml) before concentrating to yield 5-chloro-4-methyl-pyridine-2,3-diamine hydrochloride (1 g). NMR (CDCl3) δ 7.39 (s, 1H), 2.29 (s, 3H).
後処理
- filtrationfiltered through Celite and to the filtrate
- additionwas added conc. HCl (1 ml)
- concentrationbefore concentrating
出典と根拠
- ORDレコード
- ord-1b9cd93415cc458a8d7ce382b2a97452
- 出典データセット
- uspto-grants-2008_12
- 特許番号
- US07462600B2
反応ノート
読み込み中…