Sodium Hydroxide → 6-Pyridin-2-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid

HRID 2374776

反応式

C(OC1C=CC(C2CC(C(O)=O)C(=O)NN=2)=CC=1)C1C=CC=CC=1.[N:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:31]1[CH:32]=[C:33]([C:38]([O:40]CC)=[O:39])[C:34](=[O:37])[NH:35][N:36]=1.[OH-].[Na+]>Cl>[N:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:31]1[CH2:32][CH:33]([C:38]([OH:40])=[O:39])[C:34](=[O:37])[NH:35][N:36]=1

参加物

実験手順

Working as in example 19 for the preparation of 6-[4-(benzyloxy)phenyl]-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid, but starting with 4 g of ethyl 6-pyridin-2-yl-3-oxo-2,3-dihydropyridazine-4-carboxylate, 49 cm3 of one molar sodium hydroxide solution and 50 cm3 of one molar hydrochloric acid solution, 3.44 g of 6-pyridin-2-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid were obtained in the form of a beige-colored solid melting at a temperature above 260° C.

出典と根拠

ORDレコード: ord-942ff03a60c84e49a074b9376cf4a383
出典データセット: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07462613B2

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

実験手順

出典と根拠

関連ノート