Lithium Hydroxide → {[(1-Ethyl-1-methylpropoxy)carbonyl]amino}acetic acid
反応式
[CH2:1]([C:3]([CH3:16])([O:6][C:7]([NH:9][CH2:10][C:11]([O:13]CC)=[O:12])=[O:8])[CH2:4][CH3:5])[CH3:2].[OH-].[Li+]>CO.O>[CH2:1]([C:3]([CH3:16])([O:6][C:7]([NH:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8])[CH2:4][CH3:5])[CH3:2]参加物
4
実験手順
300 mg (1.30 mmol) of ethyl {[(1-ethyl-1-methylpropoxy)carbonyl]-amino}acetate was dissolved in 2.5 ml of a solvent mixture of methanol:water (2.3:1). 1.56 ml of 1 N aqueous lithium hydroxide solution was added to the obtained solution. After stirring at room temperature for 2 hours, “DOWEX” (50W-X2 100 to 200 mesh H form) (an exchange resin of The Dow Chemical Company) was added to the reaction mixture under gentle stirring until pH of the mixture had become 5. The resin was obtained by the filtration under suction and then the filtrate was concentrated under reduced pressure and then dried to obtain the title compound.