Water → (S)-3-(4-Bromo-3,5-dimethyl-phenoxy)-2-methyl-propan-1-ol

HRID 237500ノート

反応式

HRID 237500 の反応式
Br[CH2:2][C@@H:3]([CH3:6])[CH2:4][OH:5].[Br:7][C:8]1[C:13]([CH3:14])=[CH:12][C:11]([OH:15])=[CH:10][C:9]=1[CH3:16].C(=O)([O-])[O-].[K+].[K+].O>C(#N)C>[Br:7][C:8]1[C:13]([CH3:14])=[CH:12][C:11]([O:15][CH2:2][C@@H:3]([CH3:6])[CH2:4][OH:5])=[CH:10][C:9]=1[CH3:16]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 819704-Bromo-3,5-dimethylphenolHCID 10986449(S)-(+)-3-Bromo-2-methyl-1-propanol

生成物 1

HCID 86697161(S)-3-(4-Bromo-3,5-dimethyl-phenoxy)-2-methyl-propan-1-ol

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

(S)-3-Bromo-2-methyl-1-propanol (150 mg), 4-bromo-3,5-dimethylphenol (98.5 mg) and potassium carbonate are stirred in 5 mL of acetonitrile at 80° C. for 4 h. The reaction mixture is cooled to room temperature, water is added and the reaction mixture is extracted with diethyl ether. The organic phase is separated, dried over sodium sulfate and concentrated under vacuum to give a solid, used in the next step without further purification. Yield: 130 mg.

後処理

  1. extractionthe reaction mixture is extracted with diethyl ether
  2. customThe organic phase is separated
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under vacuum
  5. customto give a solid
  6. customused in the next step without further purification

出典と根拠

ORDレコード
ord-f9e343ff26554e5aa368257b928847e3
出典データセット
uspto-grants-2014_02
特許番号
US08642585B2

反応ノート

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