N,N,3,5-Tetramethyl-4-nitrobenzamide → 4-amino-N,N,3,5-tetramethylbenzamide
反応式
[CH3:1][N:2]([CH3:16])[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([N+:11]([O-])=O)=[C:6]([CH3:14])[CH:5]=1.[H][H]>[Pd].CO>[NH2:11][C:7]1[C:8]([CH3:10])=[CH:9][C:4]([C:3]([N:2]([CH3:16])[CH3:1])=[O:15])=[CH:5][C:6]=1[CH3:14]参加物
5
実験手順
10% Palladium on carbon (100 mg) is added to a solution of N,N,3,5-tetramethyl-4-nitrobenzamide (1 g) in methanol (10 mL) and the mixture is hydrogenated for 3 hours under 2 bar hydrogen pressure. Then the catalyst is filtered off and washed with methanol. The combined mother liquors are concentrated to give the title compound. Yield: 1 g; LC (method 20): tR=2.75 min; Mass spectrum (ESI+): m/z=193 [M+H]+.
後処理
- filtrationThen the catalyst is filtered off
- washwashed with methanol
- concentrationThe combined mother liquors are concentrated
出典と根拠
- ORDレコード
- ord-a000bc74508e4ab981e6d592631e2633
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642585B2
反応ノート
読み込み中…