N,3,5-Trimethyl-4-nitrobenzamide → 4-amino-N,3,5-trimethylbenzamide

HRID 237519ノート

反応式

HRID 237519 の反応式
[CH3:1][NH:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([N+:11]([O-])=O)=[C:6]([CH3:14])[CH:5]=1.[H][H]>[Pd].CO>[NH2:11][C:7]1[C:6]([CH3:14])=[CH:5][C:4]([C:3]([NH:2][CH3:1])=[O:15])=[CH:9][C:8]=1[CH3:10]

参加物

5

反応物 2

HCID 86697180N,3,5-Trimethyl-4-nitrobenzamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 668742744-amino-N,3,5-trimethylbenzamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

10% Palladium on carbon (100 mg) is added to a solution of N,3,5-trimethyl-4-nitrobenzamide (1 g) in methanol (10 mL) and the mixture is hydrogenated for 3 hours under 3 bar hydrogen pressure. Then the catalyst is filtered off and washed with methanol. The combined mother liquors are concentrated to give the title compound. Yield: 850 mg; LC (method 21): tR=6.02; Mass spectrum (ESI+): m/z=179 [M+H]+.

後処理

  1. filtrationThen the catalyst is filtered off
  2. washwashed with methanol
  3. concentrationThe combined mother liquors are concentrated

出典と根拠

ORDレコード
ord-9faac96f7a6f422bb76c273f4b757674
出典データセット
uspto-grants-2014_02
特許番号
US08642585B2

反応ノート

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