Oxalyl chloride → 1-(4-Methoxyphenyl)cyclohexanecarbonyl chloride

HRID 2375235

反応式

HRID 2375235 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:15]([OH:17])=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.C(Cl)(=O)C([Cl:21])=O>ClCCl.CN(C)C=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:15]([Cl:21])=[O:17])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 819791-(4-Methoxyphenyl)cyclohexanecarboxylic acid

生成物 1

HCID 27596461-(4-Methoxyphenyl)cyclohexanecarbonyl chloride収率 101.4%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

反応条件

温度
40 °C

実験手順

To a solution of 1-(4-methoxyphenyl)-cyclohexanecarboxylic acid (1/1) (0.075 g, 0.32 mmol) in dry dichloromethane (2 ml) under argon atmosphere at ice bath temperature oxalyl chloride (0.327 g, 2.57 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at room temperature for 15 minutes and at 40° C. for 1 hour, then concentrated under reduced pressure to give crude title compound (0.082 g, ca. 100%). The crude product was immediately utilized in the next step of the synthesis without further purification.

後処理

  1. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-f17804f6431544a68ae8d79304599554
出典データセット
uspto-grants-2008_12
特許番号
US07465719B2

関連ノート

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