{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester → ((S)-6-{(R)-7-Fluoro-4-[4-(2-hydroxy-2-methyl-propylcarbamoyl)-2,6-dimethyl-phenyl]indan-1-yloxy}-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester

HRID 237524

反応式

HRID 237524 の反応式
Br[C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C@H:6]2[O:12][C:13]1[CH:26]=[CH:25][C:16]2[C@H:17]([CH2:20][C:21]([O:23][CH3:24])=[O:22])[CH2:18][O:19][C:15]=2[CH:14]=1.Br[C:28]1[C:41]([CH3:42])=[CH:40][C:31]([C:32]([NH:34][CH2:35][C:36]([OH:39])([CH3:38])[CH3:37])=[O:33])=[CH:30][C:29]=1[CH3:43]>>[CH3:24][O:23][C:21](=[O:22])[CH2:20][C@H:17]1[C:16]2[CH:25]=[CH:26][C:13]([O:12][C@H:6]3[C:7]4[C:3](=[C:2]([C:28]5[C:41]([CH3:42])=[CH:40][C:31]([C:32](=[O:33])[NH:34][CH2:35][C:36]([OH:39])([CH3:38])[CH3:37])=[CH:30][C:29]=5[CH3:43])[CH:10]=[CH:9][C:8]=4[F:11])[CH2:4][CH2:5]3)=[CH:14][C:15]=2[O:19][CH2:18]1

参加物

3

反応物 2

HCID 86697103{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 866971884-bromo-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide

生成物 1

HCID 86697187((S)-6-{(R)-7-Fluoro-4-[4-(2-hydroxy-2-methyl-propylcarbamoyl)-2,6-dimethyl-phenyl]indan-1-yloxy}-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester

実験手順

The title compound is prepared following a procedure analogous to that described in Step 5 in the preparation of Intermediate 1, starting from 4-bromo-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide.

出典と根拠

ORDレコード
ord-62f3b4a34b2d4b879b0bca427d828b9a
出典データセット
uspto-grants-2014_02
特許番号
US08642585B2

関連ノート

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