Water → 4-amino-8-(4-methoxy-3-pyridyl)-N-propyl-cinnoline-3-carboxamide

HRID 2375621ノート

反応式

HRID 2375621 の反応式
[NH2:1][C:2]1[C:11]2[C:6](=[C:7](I)[CH:8]=[CH:9][CH:10]=2)[N:5]=[N:4][C:3]=1[C:13]([NH:15][CH2:16][CH2:17][CH3:18])=[O:14].C(=O)(O)[O-].[Na+].O.[CH3:25][O:26][C:27]1[CH:32]=[CH:31][N:30]=[CH:29][C:28]=1B(O)O>COCCOC.C(Cl)Cl.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([C:28]3[CH:29]=[N:30][CH:31]=[CH:32][C:27]=3[O:26][CH3:25])[CH:8]=[CH:9][CH:10]=2)[N:5]=[N:4][C:3]=1[C:13]([NH:15][CH2:16][CH2:17][CH3:18])=[O:14]

参加物

8

反応物 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 27625564-Methoxypyridine-3-boronic acid2 回HCID 140123274-amino-8-iodo-N-propyl-cinnoline-3-carboxamide

生成物 1

HCID 236300654-amino-8-(4-methoxy-3-pyridyl)-N-propyl-cinnoline-3-carboxamide収率 60.2%

試薬・触媒・溶媒 3

HCID 178418397HCID 178418397、化合物触媒HCID 6344Dichloromethane溶媒HCID 80711,2-Dimethoxyethane溶媒

実験手順

To a stirred solution of 4-amino-8-iodo-N-propyl-cinnoline-3-carboxamide (1.00 g, 2.81 mmol), sodium bicarbonate (473 mg, 5.62 mmol) and tetrakis(triphenylphosphine)palladium(0) (974 mg, 0.84 mmol) in 1,2-dimethoxyethane (180 mL)/water (30 mL) at 85° C. under nitrogen was added the aqueous solution of 4-methoxy-pyridine-3-boronic acid (25 mg/mL) dropwise, maintaining the internal temperature between 80° C. and 85° C. The reaction was monitored by HPLC until completed. Upon the completion, 2.42 equivalents of 4-methoxy-pyridine-3-boronic acid (1.16 g, 6.80 mmol) were applied. The reaction mixture was diluted with methylene chloride (300 mL), washed with water twice, dried through MgSO4, and then the solvent was evaporated. The residual was purified by flash chromatography using a gradient of methanol in methylene chloride to give a yellow solid. The yellow solid was crystallized from methylene chloride/methanol (2/1) to give an off-white needle crystal as the title compound (570 mg, 60.2% yield). 1H NMR (300 MHz, CDCl3) δ 8.58 (d, J=5.8 Hz, 1H), 8.53 (br, 1H), 5.11 (m, 6H), 8.46 (s, 1H), 7.94 (t, J=4.9 Hz, 1H), 7.74 (d, J=4.8 Hz, 2H), 6.96 (d, J=5.8 Hz, 1H), 3.78 (s, 3H), 3.45 (q, J=6.7 Hz, 2H), 1.66 (m, overlapped with H2O), 1.00 (t, J=7.4 Hz, 3H) MS APCI, m/z=338 (M+H) HPLC 1.28 min.

後処理

  1. temperaturemaintaining the internal temperature between 80° C. and 85° C
  2. washwashed with water twice
  3. dry with materialdried through MgSO4
  4. customthe solvent was evaporated
  5. customThe residual was purified by flash chromatography
  6. customto give a yellow solid
  7. customThe yellow solid was crystallized from methylene chloride/methanol (2/1)

出典と根拠

ORDレコード
ord-469a8644952e4754bf9ca486b37a5af7
出典データセット
uspto-grants-2008_12
特許番号
US07465795B2

反応ノート

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