HCID 68967238、化合物 → 2-(pyrrolidin-1-ylmethyl)aniline

HRID 2376163ノート

反応式

HRID 2376163 の反応式
C([CH:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-])=O)C>[Pd].CO>[N:4]1([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:15])[CH2:5][CH2:6][CH2:7][CH2:3]1

参加物

4

反応物 1

HCID 68967238HCID 68967238、化合物

生成物 1

HCID 2643112-(pyrrolidin-1-ylmethyl)aniline収率 115.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of ethyl 1-(2-nitrobenzyl)pyrrolidine (1.90 g) and 10% palladium on carbon (200 mg) in methanol (40 mL) was hydrogenated at ambient temperature. After completion of the reaction, the catalyst in the reaction mixture was removed by filtration. The solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography (chloroform/methanol=20/1 v/v) to give [2-(1-pyrrolidinylmethyl)phenyl]amine (1.65 g) as a pale yellow solid.

後処理

  1. customwas hydrogenated at ambient temperature
  2. customAfter completion of the reaction
  3. customthe catalyst in the reaction mixture was removed by filtration
  4. customThe solvent was evaporated in vacuo
  5. customThe residue was purified by silica gel column chromatography (chloroform/methanol=20/1 v/v)

出典と根拠

ORDレコード
ord-af209a647af441289dcc1e5da739eb1a
出典データセット
uspto-grants-2008_12
特許番号
US07465731B2

反応ノート

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