Thionyl Chloride → 6-Chloropyridine-3-carbonyl chloride--hydrogen chloride (1/1)
反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][N:3]=1.O=S(Cl)[Cl:13]>>[ClH:1].[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:13])=[O:7])=[CH:4][N:3]=1参加物
3
実験手順
A solution of 6-chloronicotinic acid (10.00 g, 63.5 mmol) in SOCl2 (37 mL) was heated to reflux for 2 h. The SOCl2 was evaporated to dryness, to afford 12.56 g of the desired product (yield: 93%).
後処理
- temperatureto reflux for 2 h
- customThe SOCl2 was evaporated to dryness
出典と根拠
- ORDレコード
- ord-dc9d9151420a4109a22000a9d6242203
- 出典データセット
- uspto-grants-2008_12
- 特許番号
- US07468376B2
反応ノート
読み込み中…