Methanol → N1-Methyl-5-amino-1H-1-indolecarboxamide
反応式
CO.[Cl-].[NH4+].[CH3:5][NH:6][C:7]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([N+:18]([O-])=O)=[CH:15][CH:16]=2)[CH:11]=[CH:10]1)=[O:8]>[Fe].O>[CH3:5][NH:6][C:7]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([NH2:18])=[CH:15][CH:16]=2)[CH:11]=[CH:10]1)=[O:8]参加物
6
実験手順
Methanol (6 ml), water (2 ml), iron (0.32 g) and ammonium chloride (0.64 g) were added to N1-methyl-5-nitro-1H-1-indolecarboxamide (0.32 g, 1.46 mmol) synthesized in Production example 218-1; and the reaction mixture was heated to reflux for 2 hours. The reaction mixture was partitioned between ethyl acetate and water; the organic layer was washed with water and brine, and dried over anhydrous sodium sulfate. The residue was filtrated with celite, and concentrated under reduced pressure to yield the title compound (210 mg).
後処理
- customsynthesized in Production example 218-1
- temperatureand the reaction mixture was heated
- temperatureto reflux for 2 hours
- customThe reaction mixture was partitioned between ethyl acetate and water
- washthe organic layer was washed with water and brine
- dry with materialdried over anhydrous sodium sulfate
- filtrationThe residue was filtrated with celite
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-04faaaff43d3457f9820bf0ed779139e
- 出典データセット
- uspto-grants-2008_12
- 特許番号
- US07468380B2
反応ノート
読み込み中…