Isopropylamine → Isopropylpent-4-enylamine

反応式

Br[CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6].[CH:7]([NH2:10])([CH3:9])[CH3:8]>>[CH:7]([NH:10][CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6])([CH3:9])[CH3:8]

参加物

反応物 2

HCID 6363Isopropylamine

HCID 707041-Pentene, 5-bromo-

生成物 1

HCID 551578Isopropylpent-4-enylamine収率 40%

反応条件

温度: 60 °C

実験手順

5-Bromo-1-pentene (42.3 mmol) was added to isopropylamine (423 mmol), and the mixture was stirred at 60° C. for 48 h in the dark in a sealed tube. Then the volatiles were evaporated at reduced pressure and the crude residue was dissloved in 50 mL of diethyl ether and washed twice with water. The organic phase was dried over Na2SO4. Evaporation of the solvent gave N-isopropylpent-4-en-1-amine as brownish oil (40%) which was used without any further purification.

後処理

customThen the volatiles were evaporated at reduced pressure
washwashed twice with water
dry with materialThe organic phase was dried over Na2SO4
customEvaporation of the solvent

出典と根拠

ORDレコード: ord-a99b8692e57248e7be131da6ec9e231f
出典データセット: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07470664B2

反応ノート

読み込み中…

参加物