Dimethylformamide → Methyl 4-ethoxy-6-fluoroquinoline-2-carboxylate

HRID 2377796ノート

反応式

HRID 2377796 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([C:12]([O:14][CH3:15])=[O:13])=[CH:6][C:5]2=[O:16].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C.I[CH2:29][CH3:30]>O>[CH2:29]([O:16][C:5]1[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=2)[N:8]=[C:7]([C:12]([O:14][CH3:15])=[O:13])[CH:6]=1)[CH3:30]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 11390401Methyl 6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate

生成物 1

HCID 11242121Methyl 4-ethoxy-6-fluoroquinoline-2-carboxylate

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

8.0 g (0.036 M) of methyl 6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate and 15.0 g (0.108 M) of potassium carbonate are introduced into 80 ml of DMF. The reaction mixture is stirred for 1 hour at 50° C. After addition of 3.0 ml (0.037 M) of iodoethane and heating for 12 hours at 50° C., the reaction medium is poured into 400 ml of demineralized water. A brown solid precipitates out. The solid is filtered off, washed thoroughly with water and then with isopropyl ether, and finally dried under vacuum at 40° C.

後処理

  1. temperatureheating for 12 hours at 50° C.
  2. customA brown solid precipitates out
  3. filtrationThe solid is filtered off
  4. washwashed thoroughly with water
  5. dry with materialwith isopropyl ether, and finally dried under vacuum at 40° C.

出典と根拠

ORDレコード
ord-91e3bb3cb59048bc9cffdde48d63dea7
出典データセット
uspto-grants-2008_12
特許番号
US07470708B2

反応ノート

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