1-tert-Butyl-2-(2-nitrophenoxy)benzene → HCID 5104180、化合物
反応式
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N+:18]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>CO.C1COCC1.[Pd]>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[NH2:18])([CH3:4])([CH3:2])[CH3:3]参加物
4
実験手順
To a solution of 1-tert-butyl-2-(2-nitrophenoxy)benzene (˜20 g, crude) in MeOH/THF (1:1, 200 mL) was added 10% Pd/C (2 g). The mixture was hydrogenated under 75 psi overnight. The mixture was filtered through Celite® cake and the filtrate was evaporated to give the crude product as a black oil. Purification by flash chromatography (0-30% EtOAc/hexane) provided 135a (11 g) as a brown solid.
後処理
- customwas hydrogenated under 75 psi overnight
- filtrationThe mixture was filtered through Celite® cake
- customthe filtrate was evaporated
- customto give the crude product as a black oil
- customPurification by flash chromatography (0-30% EtOAc/hexane)
出典と根拠
- ORDレコード
- ord-4cd880e7e7154078892d2a2b9658f812
- 出典データセット
- uspto-grants-2008_12
- 特許番号
- US07470712B2
反応ノート
読み込み中…