Trifluoroacetic acid → HCID 178494191、化合物
反応式
[I:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([O:8][CH3:9])[C:3]=1[C:10]1[NH:11][C:12]([C:16]([O:18]C(C)(C)C)=[O:17])=[C:13]([CH3:15])[N:14]=1.FC(F)(F)C(O)=O>ClCCl>[I:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([O:8][CH3:9])[C:3]=1[C:10]1[NH:11][C:12]([C:16]([OH:18])=[O:17])=[C:13]([CH3:15])[N:14]=1参加物
4
実験手順
A stirred solution of tert-butyl 2-(4-iodo-2-methoxypyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylate (0.047 g, 0.1131 mmol) in dichloromethane (0.8 mL) was added trifluoroacetic acid (0.6 mL) and the reaction was stirred at room temperature overnight. The solvent was evaporated after adding toluene (1 mL) and the residue was purified on Prep HPLC (trifluoroacetic acid/acetonitrile/water) to give the title material (0.039 g, 96%). 1H NMR (400 MHz, MeOH-d4) δ (ppm): 2.70 (s, 3H) 3.97 (s, 3H) 7.70 (d, J=5.56 Hz, 1H) 8.11 (d, J=5.56 Hz, 1H).