1-Benzyloxy-4-(3,3,5,5-tetramethyl-cyclohex-1-enyl)-benzene → 4-(3,3,5,5-Tetramethyl-cyclohexyl)-phenol

HRID 237811ノート

反応式

HRID 237811 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH2:20][C:19]([CH3:22])([CH3:21])[CH2:18][C:17]([CH3:24])([CH3:23])[CH:16]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.CCOC(C)=O.[Pd]>[CH3:23][C:17]1([CH3:24])[CH2:18][C:19]([CH3:21])([CH3:22])[CH2:20][CH:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=2)[CH2:16]1

参加物

5

反応物 1

HCID 685258151-Benzyloxy-4-(3,3,5,5-tetramethyl-cyclohex-1-enyl)-benzene

生成物 1

HCID 685258634-(3,3,5,5-Tetramethyl-cyclohexyl)-phenol収率 96.6%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To 10% Pd/C (0.17 g) under N2 was added 1-benzyloxy-4-(3,3,5,5-tetramethyl-cyclohex-1-enyl)-benzene (1.7 g, 5.3 mmol), prepared by a substantially similar procedure to that of Step 1 of Example 18, in MeOH (15 mL) and EtOAc (15 mL). This mixture was stirred under H2 (1 atm) overnight. The reaction mixture was filtered through celite. The filtrate was concentrated to give the title compound as a white solid (1.19 g).

後処理

  1. customprepared by a substantially similar procedure to that of Step 1 of Example 18
  2. filtrationThe reaction mixture was filtered through celite
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-8b5b782ad61043aab7f5d69373edc6f7
出典データセット
uspto-grants-2014_02
特許番号
US08642603B2

反応ノート

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