Phosgene → Pentafluorophenyl chloroformate

HRID 2378147ノート

反応式

HRID 2378147 の反応式
[F:1][C:2]1[C:7]([OH:8])=[C:6]([F:9])[C:5]([F:10])=[C:4]([F:11])[C:3]=1[F:12].C(N(CC)CC)C.[C:20](Cl)([Cl:22])=[O:21]>C1COCC1.C1(C)C=CC=CC=1>[Cl:22][C:20]([O:8][C:7]1[C:2]([F:1])=[C:3]([F:12])[C:4]([F:11])=[C:5]([F:10])[C:6]=1[F:9])=[O:21]

参加物

6

反応物 3

HCID 6371PhosgeneHCID 8471TriethylamineHCID 13041Pentafluorophenol

生成物 1

HCID 14090568Pentafluorophenyl chloroformate収率 75%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Pentafluorophenol (30 g; 163 mmol) and triethylamine (20 g, 200 mmol) were combined in 200 ml dry THF, and then added dropwise to a stirring solution of phosgene (20 g; 200 mmol) in 100 ml of toluene at 0° C. After 2 hours, the solution was filtered and evaporated to give the crude product as an oil, which was recrystallized from hexane to obtain 30 g (75%) pure pentafluorophenyl chloroformate.

後処理

  1. filtrationthe solution was filtered
  2. customevaporated
  3. customto give the crude product as an oil, which
  4. customwas recrystallized from hexane

出典と根拠

ORDレコード
ord-676981e65ad0474f92f66873a89d5864
出典データセット
uspto-grants-2008_12
特許番号
US07470783B2

反応ノート

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