HCID 69205838、化合物 → HCID 69204178、化合物

HRID 2378275ノート

反応式

HRID 2378275 の反応式
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N:20]3[CH:24]=[CH:23][CH:22]=[CH:21]3)[CH:15]=2)[OH:13])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2]>C(Cl)Cl.O=[Mn]=O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N:20]3[CH:24]=[CH:23][CH:22]=[CH:21]3)[CH:15]=2)=[O:13])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2]

参加物

4

反応物 1

HCID 69205838HCID 69205838、化合物

生成物 1

HCID 69204178HCID 69204178、化合物

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒2 回HCID 6344Dichloromethane溶媒

実験手順

A mixture of (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl) -methanol from above and activated MnO2 (2.6 g, 30 mmol) in methylene chloride (30 if L) was stirred at room temperature for 18 h. More MnO2 (2 g) was added and kept for overnight. The suspension was filtered thru a pad of Celite. Removal of solvent gave (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanone as a brown oil (1.58 g, 85% crude yield 2 steps). The sample was used in the next step without further purification.

後処理

  1. waitkept for overnight
  2. filtrationThe suspension was filtered
  3. customRemoval of solvent

出典と根拠

ORDレコード
ord-67d17ecd437d444ea959d2de81fb4211
出典データセット
uspto-grants-2008_12
特許番号
US07470723B2

反応ノート

読み込み中…