Ethyl 3-(3-fluoro-4-methyloxyphenyl)Acrylate → HCID 22558762、化合物

HRID 2378530ノート

反応式

HRID 2378530 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]>C(OCC)(=O)C.CO.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

参加物

5

反応物 1

HCID 53705486Ethyl 3-(3-fluoro-4-methyloxyphenyl)Acrylate

生成物 1

HCID 22558762HCID 22558762、化合物収率 99.4%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of Intermediate 7 (3.01 g) in ethyl acetate (50 ml) and methanol (25 ml) was added with 10% palladium/carbon (300 mg, Merck), and stirred at room temperature for 2 hours under hydrogen atmosphere. The reaction mixture was filtered, and the solvent of the filtrate was evaporated under reduced pressure to obtain the title compound (Intermediate 8, 3.02 g).

後処理

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent of the filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-3cec7341f3274df9a0847e009ebb01c9
出典データセット
uspto-grants-2008_12
特許番号
US07470807B2

反応ノート

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