Butyric Acid → 4-Butanoylresorcinol

HRID 2379171

反応式

HRID 2379171 の反応式
[C:1]1([CH:8]=[CH:7][CH:6]=[C:4]([OH:5])[CH:3]=1)[OH:2].[C:9](O)(=[O:13])[CH2:10][CH2:11][CH3:12].Cl.[Cl-].[Na+].O>ClCCCl.[Cl-].[Cl-].[Zn+2]>[C:9]([C:6]1[CH:7]=[CH:8][C:1]([OH:2])=[CH:3][C:4]=1[OH:5])(=[O:13])[CH2:10][CH2:11][CH3:12]

参加物

6

反応物 3

HCID 264Butyric AcidHCID 5054ResorcinolHCID 131718760Hydrochloric acid brine

生成物 1

HCID 781034-Butanoylresorcinol

試薬・触媒・溶媒 2

HCID 3007855Zincchloride触媒HCID 111,2-Dichloroethane溶媒

反応条件

温度
150 °C

実験手順

To a solution of resorcinol (1.5 g) and butyric acid (2.9 mL) in 1,2-dichloroethane (45 mL) was added ZnCl2 (3.22 g) and the mixture then heated at 150° C. under nitrogen for 5 hr. The reaction mixture was cooled, poured onto 1N HCl/brine and extracted (3x EtOAc). After washing with 0.1N K2CO3, then twice with brine, the organic layer was dried and evaporated. Chromatography of the residue (silica gel; hexane/EtOAc 2:1) afforded the title product as a solid.

後処理

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted (3x EtOAc)
  3. washAfter washing with 0.1N K2CO3
  4. dry with materialtwice with brine, the organic layer was dried
  5. customevaporated

出典と根拠

ORDレコード
ord-bf0c04924124472d9d82c72dd027406c
出典データセット
uspto-grants-1994_11
特許番号
US05360815

関連ノート

読み込み中…