Ethanol → HCID 86748228、化合物

HRID 2379193ノート

反応式

HRID 2379193 の反応式
[NH2:1][CH2:2][C@@H:3]([C:5]1[CH:6]=[C:7]([CH:13]=[CH:14][C:15]=1[F:16])[NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[OH:4].[C:17]([OH:26])(=[O:25])[C@@H:18]([C@H:20]([C:22]([OH:24])=[O:23])[OH:21])[OH:19].C(O)C>O>[C:22]([C@@H:20]([C@H:18]([C:17]([OH:26])=[O:25])[OH:19])[OH:21])([OH:24])=[O:23].[NH2:1][CH2:2][C@@H:3]([C:5]1[CH:6]=[C:7]([CH:13]=[CH:14][C:15]=1[F:16])[NH:8][S:9]([CH3:12])(=[O:10])=[O:11])[OH:4]

参加物

5

反応物 3

HCID 702EthanolHCID 444305L-Tartaric acidHCID 9838763137431-02-8

生成物 1

HCID 86748228HCID 86748228、化合物収率 63.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Crude (R)-(-)-3'-(2-amino-1-hydroxyethyl)-4'-fluoromethanesulfonanilide (15.8 g) and 9.6 g of L-(+)-tartaric acid were dissolved in water, ethanol was added thereto and the crystals separated out thereby were collected and repeatedly recrystallized from water-ethanol to give 16 g of (R)-(-)-3'-(2-amino-1-hydroxyethyl)-4'-fluoromethanesulfonanilide L-(+)-tartrate. M.p. 91°-92 ° C.

後処理

  1. customthe crystals separated out
  2. customthereby were collected
  3. customrepeatedly recrystallized from water-ethanol

出典と根拠

ORDレコード
ord-1f3cd80ab0454c628156bcc388ba39ff
出典データセット
uspto-grants-1994_11
特許番号
US05360822

反応ノート

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