Methyl iodide → 2-Methoxy-4-methylpyridin-3-amine

HRID 2379611ノート

反応式

HRID 2379611 の反応式
[N+:1]([C:4]1[C:5](=[O:11])[NH:6][CH:7]=[CH:8][C:9]=1[CH3:10])([O-])=O.[CH3:12]I>[Zn].C(O)(=O)C>[CH3:12][O:11][C:5]1[C:4]([NH2:1])=[C:9]([CH3:10])[CH:8]=[CH:7][N:6]=1

参加物

5

反応物 2

HCID 6328Methyl iodideHCID 3453702-Hydroxy-4-methyl-3-nitropyridine

生成物 1

HCID 103293612-Methoxy-4-methylpyridin-3-amine

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 176Acetic Acid溶媒

実験手順

3-Nitro-4-methyl-2-pyridone was methylated with methyl iodide and reduced with zinc and acetic acid to give 2-methoxy-3-amino-4-methylpyridine. This material was converted to the title compound according to the procedure described in Example 28.

出典と根拠

ORDレコード
ord-9735a17f1bb54d20abd47ea12682f749
出典データセット
uspto-grants-1994_11
特許番号
US05362878

反応ノート

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