Oxalyl chloride → 3-Fluoro-5-methoxybenzoyl chloride
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1)[C:5](O)=[O:6].C(Cl)(=O)C([Cl:16])=O>C(Cl)Cl.CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1)[C:5]([Cl:16])=[O:6]参加物
5
実験手順
3-fluoro-5-methoxybenzoic acid (5 g, 0.029 mol) was stirred in CH2Cl2 (50 ml) at 0° C. under an argon atmosphere. DMF (9 drops, catalytic) was added, followed by oxalyl chloride (12.7 ml, 0.147 mol). Reaction was warmed to room temperature then stirred under argon for one hour. Reaction was concentrated in vacuo to yield 3-fluoro-5-methoxybenzoyl chloride (BA67).
後処理
- customReaction
- customReaction
- concentrationwas concentrated in vacuo
出典と根拠
- ORDレコード
- ord-81bed34386834e2b92b6b3f50f89cbd0
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642604B2
反応ノート
読み込み中…