Sodium Hydroxide → o-Nitrophenyl cyclopropyl ketone

HRID 2380077ノート

反応式

HRID 2380077 の反応式
Br[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-:15])=[O:14])=[O:6].[OH-].[Na+]>O.C(OCC)C>[CH:4]1([C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N+:13]([O-:15])=[O:14])=[O:6])[CH2:2][CH2:3]1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 537739744-Bromo-2'-nitrobutyrophenone

生成物 1

HCID 10487947o-Nitrophenyl cyclopropyl ketone

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

A stirred mixture of 4-bromo-2'-nitrobutyrophenone (3.44 g, 0.013 mole) and NaOH (0.76 g, 0.019 mole) in water is heated at reflux temperature until reaction is complete by TLC, cooled to room temperature and extracted with diethyl ether. The ether extracts are combined, dried over Na2SO4 and concentrated in vacuo to give a dark brown liquid residue. The residue is taken up in diethyl ether, filtered through silica gel and concentrated in vacuo to give the title product as a yellow oil, identified by 1HNMR.

後処理

  1. temperatureis heated
  2. temperatureat reflux temperature
  3. customuntil reaction
  4. extractionextracted with diethyl ether
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo
  7. customto give a dark brown liquid residue
  8. filtrationfiltered through silica gel
  9. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0809fa1c0dc04d5da83ccd3896d794dd
出典データセット
uspto-grants-1994_11
特許番号
US05364968

反応ノート

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