Hydrochloric Acid → 4'-(Nonyloxy)[1,1'-biphenyl]-4-carboxylic acid

HRID 2380177

反応式

HRID 2380177 の反応式
[OH-].[Na+].[OH:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.Br[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].Cl>C(O)C>[CH2:20]([O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 127421-BromononaneHCID 14798Sodium Hydroxide2 回HCID 3015564'-Hydroxy-4-biphenylcarboxylic acid

生成物 1

HCID 36202634'-(Nonyloxy)[1,1'-biphenyl]-4-carboxylic acid収率 69%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.12 g of sodium hydroxide was dissolved in 100 ml of ethyl alcohol. Then, 2.0 g of 4-(4'-hydroxyphenyl) benzoic acid and 2.3 ml of 1-bromononane were added to the solution and refluxed for 19 hours. 50 ml of 10% aqueous sodium hydroxide solution was added and refluxed for another two hours. After cooling, concentrated HCl was dropped into the solution until it was acidic. After filtration and recrystallization from ethyl alcohol gave 2.18 g of pure product (yield 69%).

後処理

  1. temperaturerefluxed for 19 hours
  2. temperaturerefluxed for another two hours
  3. temperatureAfter cooling
  4. filtrationAfter filtration and recrystallization from ethyl alcohol

出典と根拠

ORDレコード
ord-2326ebe5abc84c5283baac9b3faab9cc
出典データセット
uspto-grants-1994_11
特許番号
US05366656

関連ノート

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