p-Toluenesulfonic acid → Methyl 2-(2-formylphenyl)acetate

HRID 2380219ノート

反応式

HRID 2380219 の反応式
[CH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=[O:11])=[O:2].[C:13]1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([O:12][CH3:13])=[O:11])=[O:2]

参加物

4

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 5289058Ortho-formylphenylacetic acid

生成物 1

HCID 12241427Methyl 2-(2-formylphenyl)acetate収率 18,652%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

24.0 g (0.15 mole) of 2-formylphenylacetic acid and 0.1 g of p-toluenesulfonic acid in 250 ml of methanol are refluxed for 2 hours. Thereafter, the solution is evaporated down, the residue is taken up in diethyl ether and the solution is washed with dilute HCl. The organic phase is separated off, dried over MgSO4 and evaporated down. The residue is purified by distillation (90° C., 0.4 mbar). 19.3 g (74%) of methyl 2-formylphenylacetate are obtained as a colorless liquid in this manner.

後処理

  1. customThereafter, the solution is evaporated down
  2. washthe solution is washed with dilute HCl
  3. customThe organic phase is separated off
  4. dry with materialdried over MgSO4
  5. customevaporated down
  6. distillationThe residue is purified by distillation (90° C., 0.4 mbar)

出典と根拠

ORDレコード
ord-53d9f15518cb4f9690c7a5d96ed510ff
出典データセット
uspto-grants-1994_11
特許番号
US05366984

反応ノート

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