Sodium Carbonate → 5-Bromo-2-chloro-6-(N,N-dimethylamino)-4-methylpyridine-3-carboxamide

HRID 2380256ノート

反応式

HRID 2380256 の反応式
[Br:1][C:2]1[C:3]([CH3:14])=[C:4]([C:12]#[N:13])[C:5]([Cl:11])=[N:6][C:7]=1[N:8]([CH3:10])[CH3:9].C(=O)([O-])[O-:16].[Na+].[Na+]>S(=O)(=O)(O)O.O>[Br:1][C:2]1[C:3]([CH3:14])=[C:4]([C:12]([NH2:13])=[O:16])[C:5]([Cl:11])=[N:6][C:7]=1[N:8]([CH3:9])[CH3:10]

参加物

5

反応物 2

HCID 10340Sodium CarbonateHCID 199600285-bromo-2-chloro-3-cyano-6-(N,N-dimethylamino)-4-methylpyridine

生成物 1

HCID 199600805-Bromo-2-chloro-6-(N,N-dimethylamino)-4-methylpyridine-3-carboxamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒

実験手順

A solution of 5-bromo-2-chloro-3-cyano-6-(N,N-dimethylamino)-4-methylpyridine (1.3 g) in concentrated sulfuric acid (3 mL) was heated at 120° C. for 10 minutes. The mixture was cooled, diluted with water (50 mL), and neutralized with saturated sodium carbonate. After extraction with methylene chloride, evaporation of the organic phase gave 1.37 g of the title compound, suitable for use in the next reaction.

後処理

  1. temperatureThe mixture was cooled
  2. extractionAfter extraction
  3. customwith methylene chloride, evaporation of the organic phase

出典と根拠

ORDレコード
ord-431956b5b40d49f0b24fe75613420e9a
出典データセット
uspto-grants-1994_11
特許番号
US05366972

反応ノート

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