2,4-Dichloro-3-nitro-6-(2-fluorophenyl)pyridine → 6-(2-Fluorophenyl)pyridin-3-amine

HRID 2380399ノート

反応式

HRID 2380399 の反応式
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[C:6](Cl)[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[N:3]=1>CO.[Pd]>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[N:3][CH:2]=1

参加物

4

反応物 1

HCID 189555872,4-Dichloro-3-nitro-6-(2-fluorophenyl)pyridine

生成物 1

HCID 189555756-(2-Fluorophenyl)pyridin-3-amine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a suspension of 2,4-dichloro-3 -nitro-6-(2-fluorophenyl)pyridine (1.6 g, 5.6 mmol) in methanol (100 ml) was added a catalytic amount of 10% palladium on carbon (100 mg). The mixture was hydrogenated at 50 psi for 8 hours then filtered through celite. The methanol was removed under reduced pressure and the residue was extracted with ethyl acetate from an aqueous solution saturated with potasssium carbonate. The extract was washed with brine, dried over sodium sulfate, filtered and concentrated to give 5-amino-2-(2-fluorophenyl)pyridine, which was used without further purification.

後処理

  1. filtrationthen filtered through celite
  2. customThe methanol was removed under reduced pressure
  3. extractionthe residue was extracted with ethyl acetate from an aqueous solution saturated with potasssium carbonate
  4. washThe extract was washed with brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-d6a4ffcff473467aa90dfde6a9ee9727
出典データセット
uspto-grants-1994_11
特許番号
US05367077

反応ノート

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